GnRH y cognición en el síndrome de Down GnRH replacement rescues cognition in Down syndrome 2 SEPTEMBER 2022 • VOL 377 ISSUE 6610.Science 377, eabq4515 (2022). DOI: 10.1126/science.abq4515   Maria Manfredi-Loza, Valerie Leysen, Michela Adamo, Isabel Paiva, Renaud Rovera, Jean-Michel Pignat, Fatima Ezzahra Timzoura, Michael Candlish, Sabiha Eddarkaoui, Samuel A.